Vaccine that protects mice from malaria developed
Scientists at the Institute Pasteur, the CNRS, or the French National Centre for Scientific Research, and Inserm, which is the French Institute of Health and Medical Research have developed a new long-lasting vaccine that protects mice against malaria, a disease that about 3.2 billion people are currently at risk of contracting.
They have experimentally developed a live, genetically attenuated vaccine for Plasmodium, the parasite responsible for the disease.
The scientists enabled the gene to induce an effective, long-lasting immune response in a mouse model by identifying and deleting one of the parasite`s genes. The scientists genetically modified strains of the Plasmodium parasite by deleting the gene that codes for the HRF, or the histamine-releasing factor, protein. The resulting mutants, which no longer expressed HRF, proved to be highly effective in triggering a potent immune response.
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