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Articles
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“The scourage called Chronic Pain” |
Chronic
pain is probably the biggest problem faced by mankind. Chronic pain
means pain persisting for more than 6 months or recurring even after
treatment. Common chronic pain conditions include chronic headache, neck
and shoulder pain, low backache, pain of the hands and legs, arthritis
pain, neurogenic pain (pain resulting from damage to the peripheral
nerves or to the central nervous system itself), psychogenic pain (pain
not due to past disease or injury or any visible sign of damage inside
or outside the nervous system). Cancer pain, pain due to failed back
surgery syndrome (pain not relived by back surgery) and pain due to
diabetes mellitus form another category. Chronic pain may cause other
symptoms or conditions, including depression and anxiety. It may also
contribute to decreased physical activity given the apprehension of
exacerbating pain. Conversely it may itself have psychosomatic or
psychogenic component to its cause.Studies have shown that chronic pain
impairs the ability to direct attention and people with high-intensity
chronic pain have significantly reduced ability to perform
attention-demanding tasks. In experimental testing, two-thirds of
individuals with chronic pain demonstrate clinically significant
impairment of attention, independent of age, education, medication and
sleep disruption, suggesting that pain diminishes working memory.
Chronic pain may be caused by many conditions and situations. Anything
from a bad mattress to bad posture to highly malignant tumours can cause
chronic pain. Chronic pain then develops a psychological dimension which
perpetuates the process.
As we all know chronic pain affects our day to day life. Unfortunately
these patients go from doctor to doctor getting pain killers or worse
they self medicate. Most painkillers when used repeatedly can affect the
kidneys (analgesic nephropathy) and the heart (heart failure). Chronic
pain disables more people than cancer or heart disease. It costs the
U.S. economy more than $90 billion per year in medical costs, disability
payments, and productivity. Yet it has received little attention from
medical researchers until recently and is one of the most under funded
major health problems. In our country also people were not bothered
about chronic pain till recently but the awareness is getting on. For
every person seeking relief from chronic pain, others are inevitably
affected: husbands and wives, parents and children, friends, employers
and co-workers. Chronic pain can interfere with every aspect of a
person's life: work, relationships, self-esteem, and emotional
well-being. Chronic pain brings a burden of depression, anxiety,
frustration, fatigue, isolation, and lowered self-esteem. Pain makes it
hard to work, hard to play, hard to get support from others, and hard to
live a happy life. Chronic pain shatters productive lives. Studies have
also found association between chronic pain and infertility in women.
Treatment of chronic pain usually involves medicines and supportive
therapy. Medicines used for chronic pain include anti-inflammatory
drugs, antidepressants and anticonvulsants. Different types of medicines
help people with different types of pain. Several types of therapy can
help ease your pain. Physical therapy (such as stretching and
strengthening activities) and low-impact exercise (such as walking,
swimming or biking) can help reduce the pain. However, exercising too
much or not at all can hurt chronic pain patients. Occupational therapy
and behavioural therapy teaches you how to pace yourself and how to do
ordinary tasks differently so you won't hurt yourself. Lifestyle changes
are also an important part of treatment for chronic pain. Getting
regular sleep at night and not taking daytime naps should help.
Attention to simple activities like proper posture, the bed we sleep on
etc can make a lot of difference to some patients with chronic pain.
In those patients who are not relieved by conservative measures,
surgical measures can be advised. This is especially important in
patients with cancer pain, failed back surgery syndromes and other
complex regional pains. The main methods are intrathecal drug delivery
systems, dorsal spinal cord stimulators and deep brain stimulators.
The normal spinal cord is covered by the bony spine inside which is a
tough membrane called the duramater. Between the duramater and the
spinal cord is the subarachnoid space which is filled with the
cerebrospinal fluid (CSF). The space between the bone of the spine and
the duramater is the epidural space.
Spinal cord stimulation is the most common neurostimulatory implant
used. Here stimulating electrodes are positioned in the epidural space
of the spinal cord and the dorsal column is stimulated which causes good
relief of pain (pictures below). The pulse generator (battery) is placed
in a pouch under the skin.

Spinal cord
stimulator is indicated in failed back surgery syndrome (recurrence
or persistence of pain after apparently successful surgery),
refractory angina (patients with angina but not candidates for
angioplasty or bypass surgeryor not benefitting from these two),
diabetic neuropathy (severe pain especially in the legs at night not
controlled by drugs), brachial plexus (nerves going to the hand)
injury pain, complex regional pain syndrome, peripheral vascular
disease etc. More than 80% of patients have very good pain relief.
The surgical procedure is very simple and the complications are very
less (1 -2%), related to hardware and are reversible.
Some
conditions like pain due to cancer especially in the terminal
stages, osteoporotic pain, post stroke pain etc benefit from
intrathecal preservative free morphine which is delivered
continuously into the subarachnoid space with a pump placed (picture
above) under the skin in the anterior abdomen. A person requiring
200 mg of morphine orally will need only 1 mg of morphine
intrathecally. Compared to intravenous medications, the therapeutic
effect of intrathecal drug application lasts longer and the rate of
systemic side effects is reduced. Also there is no problem with
addiction, tolerance and drowsiness. More than 70% of patients
report very good pain relief and upto 20% report fair pain relief.
The usual complications again are related to equipment failure but
these are minor and reversible.
The same pump filled with baclofen can be used in patients with
severe spasticity due to various causes like spinal cord injury,
cerebral palsy, multiple sclerosis etc. Recently the baclofen pump
has been succesfully used in patients lying in persistant vegetative
state (coma state) for a few years.
For some resistant pain syndromes like the central post stroke pain,
deep brain stimualtion is also being used. But this is a very costly
procedure and involves brain surgery and so not very common.
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